2015/16 Taught Postgraduate Module Catalogue
CAPE5310M Chemical Process Technology and Design
30 creditsClass Size: 30
Module manager: Professor J Blacker
Email: j.blacker@leeds.ac.uk
Taught: Semesters 1 & 2 (Sep to Jun) View Timetable
Year running 2015/16
Module replaces
PEME5305M Process Chemistry and Chemical TechnologyThis module is not approved as an Elective
Module summary
- Fundamentals of the pharmaceutical and fine chemical industries including the role of process chemists and engineers, clinical trials and intellectual property.- Introduction to synthetic chemistry route selection and the use of decision matrix analysis; chemical reactions, moles and yield; stereochemical issues in pharmaceutical materials, major synthetic pathways, types of reagents.- Basic principles of industrial process chemistry: process analysis, reagent selection, solvent selection, reaction conditions; batch and continuous processes, case study - batch manufacture of aspirin and drugs such as rosuvastatin, maraviroc or saxagliptin.- Basic principles of process economics: raw materials, catalysts, operational, capital costing; profit/loss, return on investment (ROI) and plant location.- Basic principles of engineering plant design: process evaluation and selection, process flow diagram, material and energy balances, heat transfer, unit operations, sources of raw materials, uses.- Application of products, health, safety and environmental factors (illustrated through case examples of incidents/accidents involving manufacturing processes and plants). - Design project work in which students will work together in a team (with individual contributions) to design a chemical process plant. - The group supervisor will be responsible for the organisation and assessment of the project. - Students will meet with the supervisor on a regular basis to ensure good communications within the project. - Students will also attend a series of lectures and seminars dealing with relevant aspects of the planning, design and evaluation of the project.- Students will be responsible for the organisation and delivery of relevant aspects required in the project, as prescribed. Each individual student or team will be required to produce a project plan detailing the planning and execution of the project and a final report covering detailed technical design, process control, financial and environmental aspects of the project. Students will also be required to make a verbal presentation on their findings at the end of the project.Objectives
On completion of this module, students should:- have an understanding of the basic concepts surrounding pharmaceutical and fine chemical processes, design and manufacturing;
- understand the fundamentals of process chemistry, chemical technology and engineering science that underpin the synthesis of drug product ingredients and chemicals together with their process development, engineering operations and plant design;
- be capable of demonstrating chemical route and process selection based on sound scientific and engineering data and arguments;
- be aware of the safety, environmental, logistical, financial and other aspects associated with a major design project;
- have experience of project organisation and management, particularly being able to work in design teams and to communicate effectively within the team;
- have acquired the necessary skills to enable them to conduct a project with a significant degree of engineering competence;
- be capable of disseminating their findings in written and verbal form.
Learning outcomes
- Knowledge of research and development of fine chemical and pharmaceutical manufacture, together with training of fundamental engineering design and practice.
- Principles of process chemistry and mass/energy balances for complex processes with chemical reactions, combustion and recycles including:
Methodologies for design of process equipment;
Environmental and safety issues;
Project management and cost analysis.
Syllabus
- Methods for route selection
- Process chemistry
- Process engineering calculations
- Chemical technology
- Health, safety and environmental factors
- Process economics and plant location
- Design project including individual and group components.
Teaching methods
Delivery type | Number | Length hours | Student hours |
Class tests, exams and assessment | 1 | 2.00 | 2.00 |
Group learning | 22 | 4.50 | 99.00 |
Lecture | 11 | 2.00 | 22.00 |
Seminar | 2 | 1.00 | 2.00 |
Tutorial | 15 | 1.00 | 15.00 |
Private study hours | 160.00 | ||
Total Contact hours | 140.00 | ||
Total hours (100hr per 10 credits) | 300.00 |
Private study
40 hours for preparation of coursework exercises122 hours for basic research supportive design project exercise.
Opportunities for Formative Feedback
Through coursework exercises and via regular tutorials and design project meetings.Methods of assessment
Coursework
Assessment type | Notes | % of formal assessment |
Presentation | Oral presentation | 10.00 |
Group Project | Group project | 40.00 |
Assignment | Assignment | 15.00 |
In-course Assessment | Class test | 35.00 |
Total percentage (Assessment Coursework) | 100.00 |
Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated
Reading list
The reading list is available from the Library websiteLast updated: 12/01/2016
Browse Other Catalogues
- Undergraduate module catalogue
- Taught Postgraduate module catalogue
- Undergraduate programme catalogue
- Taught Postgraduate programme catalogue
Errors, omissions, failed links etc should be notified to the Catalogue Team.PROD