2016/17 Taught Postgraduate Module Catalogue
CHEM5105M Drug Discovery and Development
15 creditsClass Size: 20
Module manager: Professor C W G Fishwick
Email: C.W.G.Fishwick@leeds.ac.uk
Taught: Semester 1 (Sep to Jan) View Timetable
Year running 2016/17
Pre-requisite qualifications
BSc degree in Chemistry, Biochemistry or related subject.This module is mutually exclusive with
CHEM3145 | Med Chemistry of Drug Develop |
This module is not approved as an Elective
Module summary
An introduction to the chemistry of drug discovery and development.Objectives
The objective of this module is to provide students with exposure to key aspects of the medicinal chemistry process and the pharmaceutical industry.Key aspects involve providing students with:
(a) a comprehensive understanding of cutting edge processes and technologies used to identify drug candidates and translate these through to market; and
(b) a critical awareness of the current challenges in the drug discovery process.
Learning outcomes
On completion of this module, students should be able to:
(1) understand the pharmacokinetic and metabolic aspects of drug development;
(2) understand how drug candidates including a critical awareness of the role of contemporary types of biochemical and biophysical assay in the drug discovery process;
(3) appreciate the factors governing the production of a marketable drug;
(4) understand the role of these considerations in important chemotherapeutic areas such as antibiotics and antivirals;
(5) evaluate and critically discuss cutting edge technologies employed in contemporary drug development research.
Syllabus
- Drug Discovery Process (from target identification to market), Clinical trials and drug approval, Statistical significance and the Placebo effect (2 lectures)
- High throughput discovery technologies: Combichem, Assays/ Screening/ Z Score, HTS (3 lectures)
- the application of biophysical assays (including fluorescence, surface plasmon resonance, titration calorimetry, NMR-based methods) to critically evaluate and corroborate high throughput screening results (4 lectures)
- Metabolism - fundamentals, phase I and II metabolism, p450 etc., ADMET, distribution, excretion, toxicity (e.g. hERG) (4 lectures)
- Case studies - anitvirals OR antibacterials (basic biochemistry and elaboration of strategies) (3 lectures)
- Production of a marketable drug: Process chemistry and scale up constraints, Patents and marketing (Polymorphism) (5 lectures).
Teaching methods
Delivery type | Number | Length hours | Student hours |
Workshop | 2 | 1.00 | 2.00 |
Visit | 1 | 5.00 | 5.00 |
Class tests, exams and assessment | 1 | 2.00 | 2.00 |
Lecture | 21 | 1.00 | 21.00 |
Seminar | 1 | 2.00 | 2.00 |
Private study hours | 118.00 | ||
Total Contact hours | 32.00 | ||
Total hours (100hr per 10 credits) | 150.00 |
Private study
35 + 8 = 43 hours - reading for lectures and workshops16 hours - preparation of written work for workshops and site visit to AZ
34 hours reading research literature and preparation for oral presentations and coursework essay
25 hours - preparation for examinations.
Opportunities for Formative Feedback
Students will be formally monitored through assessed workshop work (2 pieces), oral presentation in a student-led seminar and coursework essay, attendance at lectures and contributions in workshops.Students will informally be monitored through discussions in classes - as this is expected to be a smaller class size - the delivery of lecture material will be somewhat less formal.
Methods of assessment
Coursework
Assessment type | Notes | % of formal assessment |
Essay | Written summary of research paper | 11.00 |
Tutorial Performance | Two problem solving workshops | 5.00 |
Assignment | Questionnaire associated with visit | 3.00 |
Presentation | Oral presentation on research paper | 22.00 |
Total percentage (Assessment Coursework) | 41.00 |
NB the percentages for coursework shared with CHEM3145 have been scaled in line with increasing the module from 10 to 15 credits.
Exams
Exam type | Exam duration | % of formal assessment |
Unseen exam | 2 hr 00 mins | 59.00 |
Total percentage (Assessment Exams) | 59.00 |
Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated
Reading list
The reading list is available from the Library websiteLast updated: 18/03/2016
Browse Other Catalogues
- Undergraduate module catalogue
- Taught Postgraduate module catalogue
- Undergraduate programme catalogue
- Taught Postgraduate programme catalogue
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