2016/17 Taught Postgraduate Module Catalogue

CHEM5105M Drug Discovery and Development

15 creditsClass Size: 20

Module manager: Professor C W G Fishwick
Email: C.W.G.Fishwick@leeds.ac.uk

Taught: Semester 1 (Sep to Jan) View Timetable

Year running 2016/17

Pre-requisite qualifications

BSc degree in Chemistry, Biochemistry or related subject.

This module is mutually exclusive with

CHEM3145

Med Chemistry of Drug Develop

This module is not approved as an Elective

Module summary

An introduction to the chemistry of drug discovery and development.

Objectives

The objective of this module is to provide students with exposure to key aspects of the medicinal chemistry process and the pharmaceutical industry.

Key aspects involve providing students with:
(a) a comprehensive understanding of cutting edge processes and technologies used to identify drug candidates and translate these through to market; and
(b) a critical awareness of the current challenges in the drug discovery process.

Learning outcomes
On completion of this module, students should be able to:
(1) understand the pharmacokinetic and metabolic aspects of drug development;
(2) understand how drug candidates including a critical awareness of the role of contemporary types of biochemical and biophysical assay in the drug discovery process;
(3) appreciate the factors governing the production of a marketable drug;
(4) understand the role of these considerations in important chemotherapeutic areas such as antibiotics and antivirals;
(5) evaluate and critically discuss cutting edge technologies employed in contemporary drug development research.

Syllabus

- Drug Discovery Process (from target identification to market), Clinical trials and drug approval, Statistical significance and the Placebo effect (2 lectures)
- High throughput discovery technologies: Combichem, Assays/ Screening/ Z Score, HTS (3 lectures)
- the application of biophysical assays (including fluorescence, surface plasmon resonance, titration calorimetry, NMR-based methods) to critically evaluate and corroborate high throughput screening results (4 lectures)
- Metabolism - fundamentals, phase I and II metabolism, p450 etc., ADMET, distribution, excretion, toxicity (e.g. hERG) (4 lectures)
- Case studies - anitvirals OR antibacterials (basic biochemistry and elaboration of strategies) (3 lectures)
- Production of a marketable drug: Process chemistry and scale up constraints, Patents and marketing (Polymorphism) (5 lectures).

Teaching methods

Delivery type	Number	Length hours	Student hours
Workshop	2	1.00	2.00
Visit	1	5.00	5.00
Class tests, exams and assessment	1	2.00	2.00
Lecture	21	1.00	21.00
Seminar	1	2.00	2.00
Private study hours			118.00
Total Contact hours			32.00
Total hours (100hr per 10 credits)			150.00

Private study

35 + 8 = 43 hours - reading for lectures and workshops
16 hours - preparation of written work for workshops and site visit to AZ
34 hours reading research literature and preparation for oral presentations and coursework essay
25 hours - preparation for examinations.

Opportunities for Formative Feedback

Students will be formally monitored through assessed workshop work (2 pieces), oral presentation in a student-led seminar and coursework essay, attendance at lectures and contributions in workshops.

Students will informally be monitored through discussions in classes - as this is expected to be a smaller class size - the delivery of lecture material will be somewhat less formal.

Methods of assessment

Coursework

Assessment type	Notes	% of formal assessment
Essay	Written summary of research paper	11.00
Tutorial Performance	Two problem solving workshops	5.00
Assignment	Questionnaire associated with visit	3.00
Presentation	Oral presentation on research paper	22.00
Total percentage (Assessment Coursework)		41.00

NB the percentages for coursework shared with CHEM3145 have been scaled in line with increasing the module from 10 to 15 credits.

Exams

Exam type	Exam duration	% of formal assessment
Unseen exam	2 hr 00 mins	59.00
Total percentage (Assessment Exams)		59.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated

Reading list

The reading list is available from the Library website

Last updated: 18/03/2016

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