2017/18 Taught Postgraduate Module Catalogue
CHEM5105M Drug Discovery and Development
15 creditsClass Size: 20
Module manager: Dr B Turnbull
Email: w.b.turnbull@leeds.ac.uk
Taught: Semester 1 (Sep to Jan) View Timetable
Year running 2017/18
Pre-requisite qualifications
BSc degree in Chemistry, Biochemistry or equivalentThis module is mutually exclusive with
CHEM3145 | Med Chemistry of Drug Develop |
This module is not approved as an Elective
Module summary
An introduction to the chemistry of drug discovery and developmentObjectives
The objective of this module is to provide students with exposure to key aspects of the medicinal chemistry process and the pharmaceutical industry.Key aspects involve providing students with:
(a) a comprehensive understanding of cutting edge processes and technologies used to identify drug candidates and translate these through to market; and
(b) a critical awareness of the current challenges in the drug discovery process.
Learning outcomes
On completion of this module, students should be able to:
(1) understand the pharmacokinetic and metabolic aspects of drug development;
(2) understand how high throughput hits are selected including a critical awareness of the role of contemporary types of biochemical and biophysical assay in the drug discovery process;
(3) appreciate the factors governing the production of a marketable drug;
(4) understand the role of these considerations in important chemotherapeutic areas such as antibiotics and antivirals;
(5) evaluate and critically discuss cutting edge technologies employed in contemporary drug development research.
Syllabus
- Drug Discovery Process (from target identification to market), Clinical trials and drug approval, Statistical significance and the Placebo effect (2 lectures)
- High throughput discovery technologies: Combichem, Assays/ Screening/ Z Score, HTS (3 lectures)
- the application of biophysical assays (including fluorescence, surface plasmon resonance, titration calorimetry, NMR-based methods) to critically evaluate and corroborate high throughput screening results (4 lectures)
- Metabolism – fundamentals, phase I and II metabolism, p450 etc., ADMET, distribution, excretion, toxicity (e.g. hERG) (4 lectures)
- Case studies – anitvirals OR antibacterials (basic biochemistry and elaboration of strategies) (3 lectures)
- Production of a marketable drug: Process chemistry and scale up constraints, Patents and marketing (Polymorphism) (5 lectures).
Teaching methods
Delivery type | Number | Length hours | Student hours |
Workshop | 4 | 1.00 | 4.00 |
Class tests, exams and assessment | 1 | 2.00 | 2.00 |
Lecture | 21 | 1.00 | 21.00 |
Seminar | 1 | 2.00 | 2.00 |
Private study hours | 121.00 | ||
Total Contact hours | 29.00 | ||
Total hours (100hr per 10 credits) | 150.00 |
Private study
50 hours - reading for lectures and workshops6 hours - preparation of written work for workshops
40 hours reading research literature and preparation for oral presentations and coursework essay
25 hours - preparation for examinations.
Opportunities for Formative Feedback
Formative feedback through deductive problem solving during tutorial sessions and on their paper selection prior to them delivering their oral presentation. Also feedback on oral presentation prior to them submitting their written summary.Methods of assessment
Coursework
Assessment type | Notes | % of formal assessment |
Essay | Written summary of research methods | 9.00 |
Literature Review | Identification of papers matching defined criteria | 9.00 |
Oral Presentation | Oral Presentation of research paper | 9.00 |
Computer Exercise | Critical analysis of binding data | 9.00 |
Tutorial Performance | Three deductive problem sets | 9.00 |
Total percentage (Assessment Coursework) | 45.00 |
Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated
Exams
Exam type | Exam duration | % of formal assessment |
Unseen exam | 2 hr 00 mins | 55.00 |
Total percentage (Assessment Exams) | 55.00 |
Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated
Reading list
The reading list is available from the Library websiteLast updated: 20/04/2017
Browse Other Catalogues
- Undergraduate module catalogue
- Taught Postgraduate module catalogue
- Undergraduate programme catalogue
- Taught Postgraduate programme catalogue
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