2017/18 Taught Postgraduate Module Catalogue

CHEM5226M Case Studies in Fine Chemical and Pharmaceutical Synthesis

15 creditsClass Size: 30

Module manager: Professor J Blacker
Email: j.blacker@leeds.ac.uk

Taught: Semester 2 (Jan to Jun) View Timetable

Year running 2017/18

Pre-requisite qualifications

BSc or Integrated Masters in Chemistry at IIii level or higher (or equivalent) or CHEM5116M or CHEM 5126M.

This module is not approved as an Elective

Module summary

Real world industrial case studies of relevance to fine chemical and pharmaceutical synthesis.

Objectives

To give students a detailed knowledge of real world examples of process chemistry utilising case studies from a wide variety of sources.

Learning outcomes
- Understanding of the importance of Process Chemistry
- Industrial perspective
- Opportunities and limitations of industrial applications
- Knowledge of wide variety of real examples of process chemistry in fine chemical and pharmaceutical synthesis.

Syllabus

- Choice of 6 from approximately 10 cases to study. Typical case study topics listed below. Approximately 50% of lectures will be given by industrial speakers (including Dr John Atherton and Professor John Blacker), and the remainder from within the university (Chemistry and SPEME).

- Extensive analysis of case studies in fine chemical and pharmaceutical synthesis. Detailed analysis of published examples, some through lectures, some through workshops, others by students on their own or as group.

- Industrial examples (with external speakers where appropriate) to include:
> Synthesis of chiral molecules (eg small building blocks)
> Catalysis technology; Synthesis of relatively simple drugs (eg ibuprofen)
> Synthesis of an important agrochemical
> Synthesis of complex drugs (eg taxol)
> Green chemistry aspects (eg Seldinafil)
> Polymorphism examples (eg Lamivudine)
> Continuous methods
> Process dealing with hazardous reagents
> Use and removal of precious metals, possibly incorporated with Pd-catalysis.

- A range of industrial speakers have already offered to contribute to this module including representatives from AstraZeneca, Pfizer, GlaxoSmithKline, Shasun, ChiralQuest, Syngenta, Merck Sharpe and Dohme, and Reaxa and James Robinson.

- Assessment will be by written coursework, and will be marked by speakers, and second marked by a member of academic staff with appropriate expertise.

Teaching methods

Delivery type	Number	Length hours	Student hours
Workshop	10	2.00	20.00
Lecture	10	1.00	10.00
Private study hours			120.00
Total Contact hours			30.00
Total hours (100hr per 10 credits)			150.00

Private study

- 2 hour digestion of lecture material = 20 hours
- 2 hour background reading per assignment = 12 hours
- Coursework preparation = 88 hours.

Opportunities for Formative Feedback

Formative feedback of assessed coursework.

Methods of assessment

Coursework

Assessment type	Notes	% of formal assessment
Essay	Choice of 6 out of 10 problems set related to each lecture or seminar	100.00
Total percentage (Assessment Coursework)		100.00

Coursework will involve extensive analysis of case studies in fine chemical and pharmaceutical synthesis. This will include a detailed analysis of published examples with reference to primary literature; and problems set on content of seminar (analysis, deduction, background chemistry/chemical engineering).

Reading list

There is no reading list for this module

Last updated: 30/07/2015

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