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2018/19 Taught Postgraduate Module Catalogue

MATH5880M Statistics and DNA

15 creditsClass Size: 50

Module manager: Dr Arief Gusnanto
Email: A.Gusnanto@leeds.ac.uk

Taught: Semester 2 View Timetable

Year running 2018/19

Pre-requisite qualifications

MATH2715 or MATH2735 or equivalent.

This module is mutually exclusive with

MATH3880Introduction to Statistics and DNA

This module is approved as an Elective

Module summary

Modern biological experiments produce large data sets involving information related to DNA. This module gives the basic biological background before looking at a range of data types and methods to analyse them.

Objectives

To explore a range of statistical methods pertinient to the analysis of scientific data relating to DNA.

Learning outcomes
To develop an understanding of
1. Molecular biology.
2. Analysis of evolutionary trees.
3. Statistical genetics.
4. Statistical modelling of microarrays.
5. Protein motifs and statistical models.
6. Forensic science and statistics.


Syllabus

1. Introduction to molecular biology
a) Introduction to cells, chromosomes and DNA
b) Cell division and inheritance
c) Genes, RNA and proteins

2. Evolutionary trees
a) Basic phylogenetic concepts
b) Maximum-parsimony tree construction
c) Distance-matrix tree construction

3.Statistical genetics
a) Basic concepts of genetics
b) Principles of Mendelian inheritance
c) Overview of genetic epidemiology

4. Statistical modelling of microarrays
a) Introduction to microarrays
b) Microarray data preparation
c) Identifying differentially expressed genes

5. Protein motifs and statistical models

6. Forensic science and statistics

Teaching methods

Delivery typeNumberLength hoursStudent hours
Lecture331.0033.00
Practical12.002.00
Private study hours115.00
Total Contact hours35.00
Total hours (100hr per 10 credits)150.00

Private study

- Consolidating lecture material and further reading: 53 hours
- Working on example sheets (6 sheets, 2 hours each): 12 hours
- Completing practical exercises: 30 hours
- Exam revision: 20 hours

Opportunities for Formative Feedback

Regular example sheets.

Methods of assessment


Coursework
Assessment typeNotes% of formal assessment
Practical4 practicals20.00
Total percentage (Assessment Coursework)20.00

There is no resit available for the coursework component of this module. If the module is failed, the coursework mark will be carried forward and added to the resit exam mark with the same weighting as listed above.


Exams
Exam typeExam duration% of formal assessment
Standard exam (closed essays, MCQs etc)2 hr 30 mins80.00
Total percentage (Assessment Exams)80.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated

Reading list

The reading list is available from the Library website

Last updated: 20/03/2018

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