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2019/20 Undergraduate Module Catalogue

CHEM3145 The Medicinal Chemistry of Drug Development

10 creditsClass Size: 45

Module manager: Professor C W G Fishwick
Email: C.W.G.Fishwick@leeds.ac.uk

Taught: Semester 1 View Timetable

Year running 2019/20

Pre-requisite qualifications

Level 2 in Chemistry or Medicinal Chemistry or Level 2 in Joint Honours (Science) with Chemistry or equivalent or Level 2 in MNatSci, BSc Natural Sciences.
For MSc candidates, undergraduate BSc level degree in Chemistry, Biochemistry or related subject.

This module is not approved as a discovery module

Objectives

The objective of this module is to provide students on the medicinal chemistry program with exposure to key aspects of the medicinal chemistry process and the pharmaceutical industry.

Key aspects involve providing students with:
(a) an understanding of the processes and technologies used to identify drug candidates and translate these through to market; and
(b) commercial awareness of the drug discovery process.

Learning outcomes
On completion of this module, students should be able to:
(1) understand the pharmacokinetic and metabolic aspects of drug development;
(2) understand how drug candidates are processed through clinical trials;
(3) appreciate the factors governing the production of a marketable drug;
(4) understand the role of these considerations in important chemotherapeutic areas such as antibiotics and antivirals;
(5) explain and discuss technologies used to identify drug candidates.


Syllabus

- Drug Discovery Process (from target identification to market), Clinical trials and drug approval, Statistical significance and the Placebo effect (2 lectures)
- High throughput discovery technologies: Combichem, Assays/ Screening/ Z Score, HTS (3 lectures)
- Metabolism – fundamentals, phase I and II metabolism, p450 etc., ADMET, distribution, excretion, toxicity (e.g. hERG) (4 lectures)
- Case studies – anitvirals OR antibacterials (basic biochemistry and elaboration of strategies) (3 lectures)
- Production of a marketable drug: Process chemistry and scale up constraints, Patents and marketing (Polymorphism) (5 lectures).

Teaching methods

Delivery typeNumberLength hoursStudent hours
Workshop21.002.00
Visit15.005.00
Lecture171.0017.00
Private study hours76.00
Total Contact hours24.00
Total hours (100hr per 10 credits)100.00

Private study

35 hours - reading for lectures and workshops
16 hours - preparation of written work for workshops and site visit to AZ
25 hours - preparation for examinations.

Opportunities for Formative Feedback

Students will be formally monitored through assessed workshop work (2 pieces), attendance at lectures and contributions in workshops.

Students will informally be monitored through discussions in classes - as this is expected to be a smaller class size - the delivery of lecture material will be somewhat less formal.

Methods of assessment


Coursework
Assessment typeNotes% of formal assessment
Problem SheetProblem solving workshop 14.00
Written WorkShort questionnaire associated with visit4.00
Problem SheetProblem solving workshop 24.00
Total percentage (Assessment Coursework)12.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated


Exams
Exam typeExam duration% of formal assessment
Standard exam (closed essays, MCQs etc)2 hr 00 mins88.00
Total percentage (Assessment Exams)88.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated

Reading list

The reading list is available from the Library website

Last updated: 27/06/2017

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