2019/20 Undergraduate Module Catalogue
PHYS3522 Bionanophysics 1
15 creditsClass Size: 75
Module manager: Dr Neil Thomson
Taught: Semester 1 View Timetable
Year running 2019/20
This module is mutually exclusive with
|PHYS5116M||Bionanophysics 2: Advanced Bionanophysics Research|
Module replacesPHYS 3521 Bionanophysics
This module is not approved as a discovery module
ObjectivesAt the end of this module students will have a grounding in basic understanding of the field of experimental bionanophysics. They will be familiar with the structure of the basic classes of molecules in biology (lipid, protein and nucleic acids) and how these naturally self-assemble through fundamental molecular forces. They will understand how these biomolecules are being studied and assembled for new applications in bionanotechnology. This will include single molecule biophysics techniques and applications such as DNA sequencing. Finally, they will gain insight into force generation in biological systems at a molecular level.
At the end of the module, students should be able to:
- Make effective use of physics skills and knowledge to applications in Bionanophysics.
- Collate and organise information from the published scientific literature.
- Problem solving
- Writing about complex topics in bionanophysics
- Critically analyse research literature
The course will be taught by three lecturers in individual section topics, with common concepts linking the sections.
I. THE PHYSICS OF NUCLEIC ACIDS: Molecular forces, structure and behaviour of DNA as a polymer, scanning probe microscopes, DNA molecular motors, nanopore technologies, DNA sequencing.
II. PROTEINS: Protein structure, Proteins as bionanomachines, Protein thermodynamics,
Protein mechanical stability, Protein folding and unfolding.
III. THE BIOPHYSICS OF CELL MEMBRANES: Lipid structure, the thermodynamics of lipid self-assembly, chemical forces, lateral organisation and phase separation, critical behaviour and lipid raft dynamics, membrane curvature and mechanics, bionano applications.
The course will make use of original scientific material published in high-profile journals
|Delivery type||Number||Length hours||Student hours|
|Private study hours||128.00|
|Total Contact hours||22.00|
|Total hours (100hr per 10 credits)||150.00|
Private studyReading lecture notes and recommended journal articles.
Opportunities for Formative FeedbackExample problems
Methods of assessment
|Exam type||Exam duration||% of formal assessment|
|Standard exam (closed essays, MCQs etc)||2 hr 30 mins||100.00|
|Total percentage (Assessment Exams)||100.00|
Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated
Reading listThe reading list is available from the Library website
Last updated: 20/04/2018
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