2019/20 Taught Postgraduate Module Catalogue

CHEM5601M Advanced Topics in Medicinal Chemistry 60 Credit

60 creditsClass Size: 120

Module manager: Dr Paul Thornton
Email: P.D.Thornton@leeds.ac.uk

Taught: Semesters 1 & 2 (Sep to Jun) View Timetable

Year running 2019/20

Pre-requisite qualifications

Successful completion of Level 3 programme in Chemistry

This module is not approved as an Elective

Objectives

On completion of the module, students will have an advanced level understanding of a wide range of chemistry, with a focus on medicinal chemistry, to the most advanced level. They will be able to demonstrate their knowledge and synthesis of multiple areas simultaneously and be able to explain and solve unseen problems of an advanced nature.

Ultimately the module will prepare them for postgraduate research either in academia or industry by providing the students with the core basis of advanced knowledge they will require. Through the continual assessment aspects of the module they will receive training in transferrable skills that will aid their future career.

Learning outcomes
The students will have a broad understanding of core areas of advanced chemistry and be able to solve unseen problem-led questions in these areas.

They will also be able to access the primary literature and use their knowledge to make a critical evaluation of this information.

Syllabus

The module will consist of 3 elements, two assessed by exam and one by continuous assessment.

Element 1 (first semester) will consist of 3 compulsory topics and one free choice from a list of options. Students will be required to answer unseen exam questions on at least 4 topics. The exact topic areas vary year by year to reflect research developments, but a typical list could include:

Compulsory:
- Medicinal Chemistry of pathways and computational drug design
- Completing the toolbox of organic reactions
- Chemical biology tools

At least one topic from
- Characterising Structures and Mechanisms in Inorganic Chemistry
- Metals in Medicine
- Global warming – mitigation and geo-engineering
- Principles of electrochemistry
- Advanced Applications of Colorants

For Element 2 (second semester) students will be required to study 3 compulsory topics and a free choice from a list of topics. Students will be required to answer unseen exam questions on at least 4 topics. Specific topics will vary year by year but a provisional list includes:
Compulsory:

- Strategy of synthesis for medicinal chemistry
- Asymmetric and stereoselective synthesis
- Biosynthesis and synthesis of natural products

Optional:
- Organometallics
- Metals in Biology
- Planetary atmospheres
- Electrochemical devices
- Self-assembling materials
- Delivery of Complex Fluids

For Element 3 (both semesters) students will be required to study 2 compulsory topics and 2 free choice topics from a selection of topics. This element will be assessed by a portfolio of work, based on continuous assessment of four of these topics. The exact topics will vary year by year but a provisional list includes:
Compulsory:
- Pharmaceuticals based upon biopolymers and drug delivery
- Planning and strategy of complex organic syntheses

Optional:
- Energy Transduction – Powering the Earth, Life and Society
- Nanomaterials
- Structural Control in Modern Materials
- Sustainability
- Chemical Feedback
- Molecular Dynamics
- Electronic Structure Calculations

Teaching methods

Delivery type	Number	Length hours	Student hours
Lectures	108	1.00	108.00
Seminars	12	1.00	12.00
Private study hours			480.00
Total Contact hours			120.00
Total hours (100hr per 10 credits)			600.00

Private study

Students will be presented with a wide range of advanced material and will be expected to spend considerable time consolidating this knowledge.

Additionally, they will be provided with practice problems that form the basis of the seminars for each topic.

Opportunities for Formative Feedback

Student progress will be monitored by attendance at classes and by monitoring of coursework marks for continual assessments.

Methods of assessment

Coursework

Assessment type	Notes	% of formal assessment
Portfolio	See other information below	40.00
Total percentage (Assessment Coursework)		40.00

Element 3 of the course will account for 40% of the final mark. Each topic will involve one or more of the above starred assessments. A student’s portfolio will depend upon the individual topics that students select for assessment.

Exams

Exam type	Exam duration	% of formal assessment
Standard exam (closed essays, MCQs etc)	3 hr	30.00
Standard exam (closed essays, MCQs etc)	3 hr	30.00
Total percentage (Assessment Exams)		60.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated

Reading list

There is no reading list for this module

Last updated: 05/11/2019 08:50:07

Disclaimer

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• Undergraduate module catalogue
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