2020/21 Undergraduate Module Catalogue

CARD3190 Cardiovascular Molecular Pharmacology

10 creditsClass Size: 50

Module manager: Dr Azhar Maqbool
Email: A.Maqbool@leeds.ac.uk

Taught: Semester 1 (Sep to Jan) View Timetable

Year running 2020/21

Pre-requisite qualifications

Successful completion of the first two years of an MBChB at a UK University or international equivalent. For international students, proof of proficiency in the English language will be required, a minimum of English GCSE Grade B or IELTS 7.5 (including 7.5 in spoken English), or equivalent.

Module replaces

PATH3190 Molecular Pharmacology

This module is not approved as a discovery module

Objectives

It is the aim of this module to provide an understanding of the fundamental principles of drug action at the molecular level, through examining how drugs interact with receptor molecules in the body.

Learning outcomes
On completion of this module, students should be able to:
- Discuss the fundamental role of the interaction of drugs with molecular targets (receptors) in drug action
- Explain how specificity, efficacy, and potency of drug action are due to molecular interactions between drug and receptor
- Discuss the different main classes of drug receptor molecules, giving appropriate clinically relevant examples of drug-receptor interactions
- Critically evaluate the role of cholinergic and adrenergic receptors in the peripheral nervous system and discuss drug action and clinical use at these receptors
- Apply knowledge of the molecular mechanism of some drugs that act on the central nervous system to relevant clinical situations
- Apply critical understanding to how genetics can influence the clinical response to drugs
- Discuss the molecular action of different types of anti-cancer drugs
- Apply knowledge of the molecular mechanism of some drugs that act on the cardiovascular and reproductive systems to relevant clinical situations
- Prepare and present a poster explaining the molecular mechanism of a particular drug or class of drugs

Skills outcomes
The Cardiovascular Molecular Pharmacology module enables students to develop the following subject specific skills:

- understand and demonstrate coherent and detailed subject knowledge of the role of drug receptors in the action of drugs on the body;

- understand the molecular basis of drug receptor interactions;

- use specific examples of named drugs to explain the mechanism of action of different classes of drug on a variety of tissue.

Syllabus

Pharmacology is the study of the action of drugs on the body. Over time, the mechanism of action of many drugs has been elucidated and it is now recognised that drug activity depends on the interaction of the drug with molecules within the body. It is the aim of this module to provide an understanding of the fundamental principles of drug action at the molecular level, through examining how drugs interact with receptor molecules in the body. As thousands of drugs are in use to treat a myriad number of diseases and conditions, this module cannot attempt to cover the whole of pharmacology. Instead, we will focus on the molecular action of a selected group of clinically important drugs and their receptors, including anti cancer drugs and cardiovascular drugs. From this module students should develop a general understanding of how drugs exert their effects at the molecular level, illustrated by specific examples.

Teaching methods

Delivery type	Number	Length hours	Student hours
Workshop	1	2.00	2.00
Lecture	10	1.00	10.00
Tutorial	2	1.00	2.00
Private study hours			86.00
Total Contact hours			14.00
Total hours (100hr per 10 credits)			100.00

Private study

5 hours reading per lectures;
12 hours preparation for tutorials/workshops;
24 hours coursework

Opportunities for Formative Feedback

Students receive group feedback during interactive lectures. Individual feedback is provided in the workshop.

Methods of assessment

Coursework

Assessment type	Notes	% of formal assessment
Poster Presentation	to be made before Easter vacation	30.00
Total percentage (Assessment Coursework)		30.00

The date of submission of the poster varies each year. It is clearly indicated to students in the Programme Guides and on the VLE. Compensation of marks from the separate assessed elements is permitted.

Exams

Exam type	Exam duration	% of formal assessment
Online Time-Limited assessment	2 hr	70.00
Total percentage (Assessment Exams)		70.00

Exam will be in the form of an online, open book, assessment. Duration 48-hours with an expected completion time of 2-hours or less.

Reading list

The reading list is available from the Library website

Last updated: 10/08/2020 08:42:41

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