2021/22 Taught Postgraduate Module Catalogue
CHEM5106M Drug Discovery and Development
15 creditsClass Size: 20
Module manager: Prof Bruce Turnbull
Email: w.b.turnbull@leeds.ac.uk
Taught: Semester 1 (Sep to Jan) View Timetable
Year running 2021/22
Pre-requisite qualifications
NoneThis module is mutually exclusive with
| CHEM3146 | Medicinal Chemistry |
Module replaces
CHEM5105 Drug Discovery and DevelopmentThis module is not approved as an Elective
Module summary
The module will serve as an introduction to medicinal chemistry and enable students to understand key aspects of drug discovery and development. We will cover the traditional medicinal chemistry processes of high throughput screening hit validation, lead optimisation through to the filing of a marketable drug. We will use case studies in the area of anti-infective drug discovery to highlight the holistic nature of medicinal chemistry.Objectives
The objective of this module is to provide students with exposure to the key aspects of the drug development process, using examples from the pharmaceutical industry.These key aspects include:
(a) a comprehensive understanding of the cutting edge medicinal chemistry processes and technologies required to optimise a drug candidate
(b) how a drug candidate progresses through late-lead optimisation to clinical trials
(c) a knowledge of anti-infective drug discovery with case studies from the pharmaceutical industry and academia.
Learning outcomes
On completion of this module, students should:
(1) be familiar with the drug discovery and development process, including preclinical development and clinical trials and a critical awareness of the role of contemporary types of biochemical and biophysical assay in the drug discovery process
(2) be able to understand the pharmacokinetic and metabolic aspects of drug development and apply knowledge to unseen examples.
(3) be able to explain the process of multi-parameter lead optimisation and apply to unseen examples.
(4) be familiar with the field of anti-infective drug discovery.
(5) be able to work independently to research, understand and communicate aspects of anti-infective drug discovery and
(6) be able to evaluate and critically discuss cutting edge technologies employed in contemporary drug development research
Skills outcomes
Researching primary literature relating to medicinal chemistry
Syllabus
Unit 1: Traditional medicinal chemistry (Design-Make-Test cycles, classic reactions)
Unit 2: Metabolism (Phase I and II processes, AO metabolism, blocking strategies)
Unit 3: Multiparameter lead optimisation (‘traffic-light’ systems, selection criteria, balancing physicochemical properties)
Unit 4: Translation from late-lead to marketable drug (preclinical development, Phase I, II and III clinical trials, new drug approval)
Unit 5: An introduction to antiviral drug discovery
Unit 6: An introduction to antibiotic drug discovery
Unit 7: Colorimetric and fluorescence-based assays
Unit 8: Measuring binding kinetics and thermodynamics
Unit 9: Introduction to structural biology in hit validation
Teaching methods
| Delivery type | Number | Length hours | Student hours |
| Coursework Discussion Session | 1 | 1.00 | 1.00 |
| Lecture | 3 | 1.00 | 3.00 |
| Seminar | 10 | 1.00 | 10.00 |
| Independent online learning hours | 50.00 | ||
| Private study hours | 86.00 | ||
| Total Contact hours | 14.00 | ||
| Total hours (100hr per 10 credits) | 150.00 | ||
Private study
15 hours – preparing the written report31 hours – reading, independent study and preparation for workshops
20 hours - preparation for examination
20 hours – research and preparation of oral presentation
Methods of assessment
Coursework
| Assessment type | Notes | % of formal assessment |
| Oral Presentation | 10 min presentation delivered live or as recording | 30.00 |
| Report | Written Report - 2 pages of A4 | 10.00 |
| Total percentage (Assessment Coursework) | 40.00 | |
Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated
Exams
| Exam type | Exam duration | % of formal assessment |
| Open Book exam | 2 hr | 60.00 |
| Total percentage (Assessment Exams) | 60.00 | |
If necessary the exam will be replaced by an OTLA
Reading list
There is no reading list for this moduleLast updated: 02/07/2021
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- Undergraduate module catalogue
- Taught Postgraduate module catalogue
- Undergraduate programme catalogue
- Taught Postgraduate programme catalogue
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