2017/18 Undergraduate Module Catalogue

MATH3880 Introduction to Statistics and DNA

10 creditsClass Size: 80

Module manager: Dr Arief Gusnanto
Email: A.Gusnanto@leeds.ac.uk

Taught: Semester 2 (Jan to Jun) View Timetable

Year running 2017/18

Pre-requisite qualifications

MATH2715 or MATH2735 or equivalent.

This module is mutually exclusive with

MATH5880M

Statistics and DNA

This module is approved as a discovery module

Module summary

Modern biological experiments produce large data sets involving information related to DNA. This module gives the basic biological background before looking at data on evolution, genetics and gene expression, along with methods to analyse them.

Objectives

To introduce statistical methods pertinent to the analysis of scientific data relating to DNA.

Learning outcomes
To develop a basic understanding of:
1. Molecular biology;
2. Analysis of evolutionary trees;
3. Statistical genetics;
4. Statistical modelling of microarrays.

Syllabus

1. Introduction to molecular biology
a) Introduction to cells, chromosomes and DNA
b) Cell division and inheritance
c) Genes, RNA and proteins

2. Evolutionary trees
a) Basic phylogenetic concepts
b) Maximum-parsimony tree construction
c) Distance-matrix tree construction

3. Statistical genetics
a) Basic concepts of genetics
b) Principles of Mendelian inheritance
c) Overview of genetic epidemiology

4. Statistical modelling of microarrays
a) Introduction to microarrays
b) Microarray data preparation
c) Identifying differentially expressed genes

Teaching methods

Delivery type	Number	Length hours	Student hours
Lecture	22	1.00	22.00
Practical	1	2.00	2.00
Private study hours			76.00
Total Contact hours			24.00
Total hours (100hr per 10 credits)			100.00

Private study

- Consolidating lecture material and further reading: 35 hours
- Working on example sheets (4 sheets, 2 hours each): 8 hours
- Completing practical exercises: 20 hours
- Exam revision: 12 hours

Opportunities for Formative Feedback

Regular example sheets and practical assignments.

Methods of assessment

Coursework

Assessment type	Notes	% of formal assessment
Practical	3 practicals	20.00
Total percentage (Assessment Coursework)		20.00

There is no resit available for the coursework component of this module. If the module is failed, the coursework mark will be carried forward and added to the resit exam mark with the same weighting as listed above.

Exams

Exam type	Exam duration	% of formal assessment
Standard exam (closed essays, MCQs etc)	2 hr 00 mins	80.00
Total percentage (Assessment Exams)		80.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated

Reading list

The reading list is available from the Library website

Last updated: 26/04/2017

Disclaimer

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