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2019/20 Undergraduate Module Catalogue

BIOC2301 Intermediate Integrated Biochemistry

60 creditsClass Size: 110

Module manager: Dr Joan Boyes
Email: j.m.boyes@leeds.ac.uk

Taught: Semesters 1 & 2 (Sep to Jun) View Timetable

Year running 2019/20

Pre-requisite qualifications

Successful completion of Year one of the above degree programmes

Pre-requisites

BIOC1301	Introductory Integrated Biochemistry: the Molecules and Proc
BIOC1302	Introductory Biochemistry: Practical Skills
BIOC1303	Introductory Biochemistry: Problem Solving and Data Handling

This module is not approved as a discovery module

Objectives

The module builds upon the introductory biochemistry of molecules, pathways and cells studied at level one.

Learning outcomes
On completion of this module, students will have developed knowledge and extended further their understanding along the following major themes:
1. Protein Structure and Function Theme (Semester one)
2. Genetic Engineering Theme (Semester one)
3. Cell Biology Theme (Semesters one)
4. Biological membranes Theme (Semester two)
5. Genes Theme (Semester two).

Syllabus

Semster 1:
Protein Structure and Function Theme:
- Ligand binding
- Structural biology techniques
a. mass spectometry
b. x-ray crystallography
c. electron microscopy
d. NMR
e. AFM
- Enzyme kinetics
- Protein folding
- Protein chaperones
- Antibody structure and function
- RNA biology
- Bioinformatics
- Bacterial infections.

Genetic Engineering Theme:
- Gene cloning
- DNA mutagenesis
- Recombinant protein expression systems
- RNA interference
- In vivo monitoring via GFP
- PCR and quantitative PCR

Cell Biology Theme:
Structure and function of individual organelles including:
a. the cytoskeleton
b. the nucleus
c. the endoplasmic reticulum
d. mitochondria
e. lysosymes
f. peroxisomes
g. ion channels
h. cell receptors

Cell biological techniques and high throughput technologies.
Properties of cell types including:
a. immune cells
b. endothelial cells
c. cancer cells
d. neuronal cells

Semester 2:
Membranes Theme:
a. Membranes assembly and biosynthesis
b. Photosynthesis
c. Mitochondria, electron transport and ATP synthesis
d. Transport and ion channels
e. Lipid signalling
f. Membrane signalling and second messengers
g. Plant signalling
h. Nuclear hormones.

Genes Theme:
Eukaryotic Gene expression including:
a. Epigenetics
b. Transcription factors and their modifications
c. Long range regulatory elements

The Cell cycle. Genetic diseases including:
a. Genome organisation
b. Linkage to disease markers
c. forensic analysis
d. molecular diagnosis
- V(D) J recombination
- Molecular biology of cancer.

Teaching methods

Delivery type	Number	Length hours	Student hours
Lecture	120	1.00	120.00
Private study hours			480.00
Total Contact hours			120.00
Total hours (100hr per 10 credits)			600.00

Private study

Students should note that the following information is for guidance only. The actual time required for the various elements will vary between students.
- 2.5 hours of self-study per lecture (300 hours)
- 180 hours - examination and coursework preparation.

Opportunities for Formative Feedback

- Student attendance at lectures will be monitored in line with standard faculty practice.
- Completion of coursework assessment and exam.
- Engagement with VLE resources.

Methods of assessment

Coursework

Assessment type	Notes	% of formal assessment
In-course MCQ	Protein Structure & Function	4.00
In-course MCQ	Health & Disease: Cell Biology (1)	4.00
In-course MCQ	Health & Disease: Genes(2)	4.00
In-course MCQ	Membranes & signalling	4.00
In-course Assessment	Health & Disease: Cell Biology	5.00
In-course MCQ	Genetic Engineering	4.00
Total percentage (Assessment Coursework)		25.00

Students will need to engage with VLE resources.

Exams

Exam type	Exam duration	% of formal assessment
Standard exam (closed essays, MCQs etc)	2 hr	20.00
Standard exam (closed essays, MCQs etc)	2 hr	20.00
Standard exam (closed essays, MCQs etc)	3 hr	35.00
Total percentage (Assessment Exams)		75.00

Paper 1 - week 12, MRQ and short question exam (2 hours) covering Semester 1 topics Paper 2: Semester 2 - combined MRQs and short answer questions - covering Semester 1 & 2 topics (2 hours). Paper 3: Semester 2 - Essay questions testing topics in semester 1 & 2 (3 hours).

Reading list

The reading list is available from the Library website

Last updated: 14/08/2019

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