2017/18 Taught Postgraduate Module Catalogue

MATH5880M Statistics and DNA

15 creditsClass Size: 40

Module manager: Dr Arief Gusnanto
Email: A.Gusnanto@leeds.ac.uk

Taught: Semester 2 (Jan to Jun) View Timetable

Year running 2017/18

Pre-requisite qualifications

MATH2715 or MATH2735 or equivalent.

This module is mutually exclusive with

MATH3880

Introduction to Statistics and DNA

This module is approved as an Elective

Module summary

Modern biological experiments produce large data sets involving information related to DNA. This module gives the basic biological background before looking at a range of data types and methods to analyse them.

Objectives

To explore a range of statistical methods pertinient to the analysis of scientific data relating to DNA.

Learning outcomes
To develop an understanding of
1. Molecular biology.
2. Analysis of evolutionary trees.
3. Statistical genetics.
4. Statistical modelling of microarrays.
5. Protein motifs and statistical models.
6. Forensic science and statistics.

Syllabus

1. Introduction to molecular biology
a) Introduction to cells, chromosomes and DNA
b) Cell division and inheritance
c) Genes, RNA and proteins

2. Evolutionary trees
a) Basic phylogenetic concepts
b) Maximum-parsimony tree construction
c) Distance-matrix tree construction

3.Statistical genetics
a) Basic concepts of genetics
b) Principles of Mendelian inheritance
c) Overview of genetic epidemiology

4. Statistical modelling of microarrays
a) Introduction to microarrays
b) Microarray data preparation
c) Identifying differentially expressed genes

5. Protein motifs and statistical models

6. Forensic science and statistics

Teaching methods

Delivery type	Number	Length hours	Student hours
Lecture	33	1.00	33.00
Practical	1	2.00	2.00
Private study hours			115.00
Total Contact hours			35.00
Total hours (100hr per 10 credits)			150.00

Private study

- Consolidating lecture material and further reading: 53 hours
- Working on example sheets (6 sheets, 2 hours each): 12 hours
- Completing practical exercises: 30 hours
- Exam revision: 20 hours

Opportunities for Formative Feedback

Regular example sheets.

Methods of assessment

Coursework

Assessment type	Notes	% of formal assessment
Practical	4 practicals	20.00
Total percentage (Assessment Coursework)		20.00

There is no resit available for the coursework component of this module. If the module is failed, the coursework mark will be carried forward and added to the resit exam mark with the same weighting as listed above.

Exams

Exam type	Exam duration	% of formal assessment
Standard exam (closed essays, MCQs etc)	2 hr 30 mins	80.00
Total percentage (Assessment Exams)		80.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated

Reading list

The reading list is available from the Library website

Last updated: 26/04/2017

Disclaimer

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