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2021/22 Taught Postgraduate Module Catalogue

BIOL5132M Tissue Engineering

15 creditsClass Size: 30

Module manager: Dr Hazel Fermor
Email: h.l.fermor@leeds.ac.uk

Taught: Semester 2 (Jan to Jun) View Timetable

Year running 2021/22

Pre-requisite qualifications

Undergraduate qualification in physical, clinical or biomedical science.

This module is approved as an Elective

Module summary

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Objectives

On completion of this module students will have a basic knowledge of all the major aspects of tissue engineering, namely:
- fundamentals of cell and matrix biology;
- 2 and 3 dimensional tissue culture technology;
- sterility and sterilisation procedures;
- biomechanics of tissues;
- quality control
- standardisation and regulatory issues.

Learning outcomes
On completion of this module, students should be able to:
- understand the mechanisms by which tissue allografts are rejected.
- Appreciate the need for tissue engineered constructs for the replacement of diseased traumatised tissues.
- Appreciate the needs for tissue engineered constructs for the in vitro study of disease processes and novel therapeutic approaches,
- Understand the interdisciplinary nature of tissue engineering.

Skills outcomes
Managing Knowledge - Assimilation of information; Sourcing/selecting/interpreting; Data evaluation/problem solving.
Technical Competence - IT skills.
Managing Self - Planning; Time Management.
Learning from others; Sharing; >Receiving critique.
Presentation skills - Reports; Dissertation; Oral.


Syllabus

The module begins with the basics of cell and matrix biology, cell extracellular matrix interactions, mechanical forces, growth factors, cytokines, allograft rejection, tissue repair and regeneration, tissue culture, sterilisation and aseptic technique. The module progresses to design of tissue matrices, natural matrices, enhancement of natural matrices, polymer and biodegradable scaffolds and cell interactions with synthetic surfaces. The design principles of engineering 3 dimensional cell/matrix constructs, bioreactors, the integration of physical forces into bioreactors for the production of biomechanically conditioned tissue constructs are then covered. Issues concerned with the delivery of tissues will be addressed including, durability and biocompatability testing of tissue engineered products in vitro and in vivo, quality control and standardisation, product applications and regulatory issues. Students conduct case studies of tissue engineering applied to specialised tissues and applications namely: cartilage and bone, cardiac valves, ligaments and tendons, nerves, bladder and mucosal epithelia and drug delivery.

This module will be delivered through 25 contact hours (as shown below) spread over 4 days during semester 2.

Teaching methods

Due to COVID-19, teaching and assessment activities are being kept under review - see module enrolment pages for information

Delivery typeNumberLength hoursStudent hours
Presentation13.003.00
Lecture44.0016.00
Practical14.004.00
Tutorial12.002.00
Private study hours125.00
Total Contact hours25.00
Total hours (100hr per 10 credits)150.00

Private study

Students should note that the following information is for guidance only.
The actual time required for the various elements will vary between students.
Lectures: 24 hours;
Practicals: 12 hours;
Assignment presentations: 18 hours;
Essay preparation: 15 hours;
Worksheet preparation: 18 hours;
Examination and preparation: 38 hours.

Opportunities for Formative Feedback

Practicals;
Presentation;
Assignment.
End of module examination (2 hour) choice of essay plus MCQ test: 30%

Methods of assessment

Due to COVID-19, teaching and assessment activities are being kept under review - see module enrolment pages for information


Coursework
Assessment typeNotes% of formal assessment
In-course AssessmentWorksheets 1, 2 & 320.00
PresentationPresentation/EI review (The presentation is worth 30% the mark given, is a combination of 20% tutor mark and 10% peer mark on the same presentation)30.00
AssignmentLiterature review (1,500 words) on a chosen topic20.00
Total percentage (Assessment Coursework)70.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated


Exams
Exam typeExam duration% of formal assessment
Standard exam (closed essays, MCQs etc)2 hr 30.00
Total percentage (Assessment Exams)30.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated

Reading list

The reading list is available from the Library website

Last updated: 30/06/2021 16:19:36

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