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2020/21 Undergraduate Module Catalogue
CHEM3145 The Medicinal Chemistry of Drug Development
10 creditsClass Size: 45
Module manager: Dr Richard Bourne
Email: R.A.Bourne@leeds.ac.uk
Taught: Semester 1 (Sep to Jan) View Timetable
Year running 2020/21
Pre-requisite qualifications
Level 2 in Chemistry or Medicinal Chemistry or Level 2 in Joint Honours (Science) with Chemistry or equivalent or Level 2 in MNatSci, BSc Natural Sciences.For MSc candidates, undergraduate BSc level degree in Chemistry, Biochemistry or related subject.
This module is not approved as a discovery module
Objectives
The objective of this module is to provide students on the medicinal chemistry program with exposure to key aspects of the medicinal chemistry process and the pharmaceutical industry.Key aspects involve providing students with:
(a) an understanding of the processes and technologies used to identify drug candidates and translate these through to market; and
(b) commercial awareness of the drug discovery process.
Learning outcomes
On completion of this module, students should be able to:
(1) understand the pharmacokinetic and metabolic aspects of drug development;
(2) understand how drug candidates are processed through clinical trials;
(3) appreciate the factors governing the production of a marketable drug;
(4) understand the key reactions used in drug discovery and lead optimization;
(5) explain the process of multi-parameter lead optimization and be able to give examples of such processes.'
Syllabus
- Drug Discovery & Development Process (from target identification to market), Clinical trials and drug approval, Statistical significance and the Placebo effect (2 lectures)
- Top reactions: Key reactions every medicinal chemist should know (2 lectures)
- Metabolism – fundamentals, phase I and II metabolism, AO metabolism, strategies to overcome metabolism (4 lectures)
- Multi-parameter lead optimization – the culmination of CHEM2215 and CHEM3145 ADME processes and how they are applied in drug discovery (4 lectures)
- Production of a marketable drug: Process chemistry and scale up constraints, Patents and marketing (Polymorphism) (5 lectures).'
Teaching methods
Delivery type | Number | Length hours | Student hours |
Workshop | 2 | 1.00 | 2.00 |
Visit | 1 | 5.00 | 5.00 |
Lecture | 17 | 1.00 | 17.00 |
Private study hours | 76.00 | ||
Total Contact hours | 24.00 | ||
Total hours (100hr per 10 credits) | 100.00 |
Private study
35 hours - reading for lectures and workshops16 hours - preparation of written work for workshops and site visit to AZ
25 hours - preparation for examinations.
Opportunities for Formative Feedback
Formative exercises for workshops, and regularly-spaced online quizzes.Methods of assessment
Coursework
Assessment type | Notes | % of formal assessment |
Presentation | Presentation | 25.00 |
Total percentage (Assessment Coursework) | 25.00 |
Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated
Exams
Exam type | Exam duration | % of formal assessment |
Online Time-Limited assessment | 48 hr 00 mins | 75.00 |
Total percentage (Assessment Exams) | 75.00 |
Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated
Reading list
The reading list is available from the Library websiteLast updated: 07/08/2020 18:22:56
Browse Other Catalogues
- Undergraduate module catalogue
- Taught Postgraduate module catalogue
- Undergraduate programme catalogue
- Taught Postgraduate programme catalogue
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