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2020/21 Undergraduate Module Catalogue

CHEM3145 The Medicinal Chemistry of Drug Development

10 creditsClass Size: 45

Module manager: Dr Richard Bourne

Taught: Semester 1 (Sep to Jan) View Timetable

Year running 2020/21

Pre-requisite qualifications

Level 2 in Chemistry or Medicinal Chemistry or Level 2 in Joint Honours (Science) with Chemistry or equivalent or Level 2 in MNatSci, BSc Natural Sciences.
For MSc candidates, undergraduate BSc level degree in Chemistry, Biochemistry or related subject.

This module is not approved as a discovery module


The objective of this module is to provide students on the medicinal chemistry program with exposure to key aspects of the medicinal chemistry process and the pharmaceutical industry.

Key aspects involve providing students with:
(a) an understanding of the processes and technologies used to identify drug candidates and translate these through to market; and
(b) commercial awareness of the drug discovery process.

Learning outcomes
On completion of this module, students should be able to:
(1) understand the pharmacokinetic and metabolic aspects of drug development;
(2) understand how drug candidates are processed through clinical trials;
(3) appreciate the factors governing the production of a marketable drug;
(4) understand the key reactions used in drug discovery and lead optimization;
(5) explain the process of multi-parameter lead optimization and be able to give examples of such processes.'


- Drug Discovery & Development Process (from target identification to market), Clinical trials and drug approval, Statistical significance and the Placebo effect (2 lectures)
- Top reactions: Key reactions every medicinal chemist should know (2 lectures)
- Metabolism – fundamentals, phase I and II metabolism, AO metabolism, strategies to overcome metabolism (4 lectures)
- Multi-parameter lead optimization – the culmination of CHEM2215 and CHEM3145 ADME processes and how they are applied in drug discovery (4 lectures)
- Production of a marketable drug: Process chemistry and scale up constraints, Patents and marketing (Polymorphism) (5 lectures).'

Teaching methods

Delivery typeNumberLength hoursStudent hours
Private study hours76.00
Total Contact hours24.00
Total hours (100hr per 10 credits)100.00

Private study

35 hours - reading for lectures and workshops
16 hours - preparation of written work for workshops and site visit to AZ
25 hours - preparation for examinations.

Opportunities for Formative Feedback

Formative exercises for workshops, and regularly-spaced online quizzes.

Methods of assessment

Assessment typeNotes% of formal assessment
Total percentage (Assessment Coursework)25.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated

Exam typeExam duration% of formal assessment
Online Time-Limited assessment48 hr 00 mins75.00
Total percentage (Assessment Exams)75.00

Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated

Reading list

The reading list is available from the Library website

Last updated: 07/08/2020 18:22:56


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