2022/23 Undergraduate Module Catalogue
CHEM2215 Introduction to Drug Design
10 creditsClass Size: 80
Module manager: Dr Richard Foster
Taught: Semester 1 (Sep to Jan) View Timetable
Year running 2022/23
Pre-requisite qualificationsLevel 1 in Medicinal Chemistry or equivalent
|CHEM1101||Chemistry 1: Bonding and Behaviour|
Module replacesCHEM2115 Introduction to Drug Design
This module is not approved as a discovery module
ObjectivesOn completion of this module, students should be able to:
- understand the principle modes of binding of small drug molecules to biological macromolecules;
- identify key recognition features in drug molecules;
- identify the pharmacophore and design new potential drug molecules using the principles of rational structure modification;
- interpret structure activity relationships in terms of binding models and bioavailability;
- understand basic cell signalling pathways and the role of receptor agonists and antagonists in medicinal chemistry;
- use the principles of quantitative structure activity relationships to increase the efficiency of the drug design process.
Lead Generation (3 lectures)
- Selection of therapeutic areas for drug development; Measures of drug activity in vivo and in vitro.
- Interactions of drugs with biomolecules including H-bonding and Hydrophobic interactions.
- Pharmacophore Identification.
Structure Optimisation. (9 lectures 2.5 workshops)
- Activity optimisation by: Conformational restriction, Bioisosteric replacement, exploring the binding site.
- Other factors to be optimised, Pharmacokinetics, The journey of a drug through the body, selectivity.
- Structure Activity Relationships.
Receptors as Targets (1 lectures 1 workshop)
- Cell signalling pathways and receptor mechanisms. Receptor Subtypes
- Agonists Antagonists
Quantification of structure activity relationships (2 lectures 0.5 workshop)
- The role of QSAR
- QSAR analysis
- Independence of parameters and the Craig plot
- Simplifying QSAR: the Topliss model.
Case Studies (1 lecture)
- Drug development case studies
|Delivery type||Number||Length hours||Student hours|
|Independent online learning hours||15.00|
|Private study hours||65.00|
|Total Contact hours||20.00|
|Total hours (100hr per 10 credits)||100.00|
Private study80h (including 15h online study - quizzes, note-taking, additional reading)
Opportunities for Formative FeedbackShort online MCQs. Online workshops with in-class feedback
Methods of assessment
|Exam type||Exam duration||% of formal assessment|
|Open Book exam||2 hr 00 mins||100.00|
|Total percentage (Assessment Exams)||100.00|
Normally resits will be assessed by the same methodology as the first attempt, unless otherwise stated
Reading listThe reading list is available from the Library website
Last updated: 07/07/2022 11:10:17
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